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Synthesis and Antimicrobial Activity of Schiff base metal complexes derived from Ampicillin with Vanillin
Abstract
ABSTRACT:
Metal -drug complexes compounds are more popular nowadays due to their greater biological activity than uncompleted legends of some drugs. However various studies have shown that Schiff base derived from biologically active ingredients present in natural materials in its pure form. In this paper K(I), Pb(II), Sr(II), Co(III), and Ba(II) complexes were synthesized from Schiff base derived from ampicillin and vanillin. The ligand and metal complexes have been screened for antimicrobial activity against Bacillus Sp, E-Coli, K-Pneumonia, Staphylococus aureus, Pseudomonas auruginosa and against fungal activities. Result revealed moderate change comparing the ligand.
Metal -drug complexes compounds are more popular nowadays due to their greater biological activity than uncompleted legends of some drugs. However various studies have shown that Schiff base derived from biologically active ingredients present in natural materials in its pure form. In this paper K(I), Pb(II), Sr(II), Co(III), and Ba(II) complexes were synthesized from Schiff base derived from ampicillin and vanillin. The ligand and metal complexes have been screened for antimicrobial activity against Bacillus Sp, E-Coli, K-Pneumonia, Staphylococus aureus, Pseudomonas auruginosa and against fungal activities. Result revealed moderate change comparing the ligand.
DOI: https://doi.org/10.37628/jcmm.v5i1.528
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