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A Detailed Review: Genetic Disorders and Gene Therapy

Amit Chawla, Payal Chawla, Arsh Chanana, Vikramjit Singh

Abstract


This article covers a review on genetic disorders and the various approaches to treat these genetic disorders like gene replacement, gene modification, and gene insertion. Genetic disorders may be heritable or non-heritable can be cured via biological method (viral method) or non-viral methods. The abnormality ranges from minimum to maximum–from a discrete mutation in a single base DNA of a single gene to a gross chromosome abnormality involving the addition or subtraction of an entire chromosome or set of chromosomes. Some of the genetic disorders are inherited from the parents, while other genetic diseases are caused by other acquired changes or mutations in a preexisting gene. Mutations occur either randomly or due to some environmental exposure.

 


Keywords


Gene, disorder, genetic, DNA, chromosome

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