Open Access Open Access  Restricted Access Subscription or Fee Access

Synthesis, Characterization and Anticancer Evaluation of New Quinoline Derivatives from Meldrum Acid by Many Steps

Hanan Faleh Mohsein

Abstract


This research Included synthesis of new Quinoline Derivative from Methylene Meldrum acid (2L, 2M) Record previously by many steps. Starting Conversion the Phenylamine (methylene Meldrum's acid)derivatives to substitute quinolone(3L, 3M), then reacted it with POCl3 to give the substituted 4-chloro quinoline derivative (4L, 4M) that which containing free choro group that reaction with different boronic acids in the presence of Tetrakis (triphenylphosphine) palladium (0) gives the 4-phenylquinolines (5L, 5M). Then the study Anticancer Evaluation of some new compounds. the structure of these compounds were characterized by (H1-NMR, C13-NMR, H-HCOSY NMR, FT-IR) Techniques, melting points and other physical studies.


Keywords


Quinoline Derivatives, Anti Breast cancer, DMSO-d6, EtOH, Methylene Meldrum acid Compounds

Full Text:

PDF

References


X.F Shang, S.L. Morris-Natschke, Y.Q. Liu. "Biologically active quinoline and quinazoline alkaloids part I." Medicinal Research Reviews. 38 (3): (2018) 775–828. doi:10.1002/med.21466.

S. Xiao-Fei, M. Natschke, L. Susan, Y.G. Zhou, L.Y. Qian. "Biologically active quinoline and quinazoline alkaloids part II". Medicinal Research Reviews. 38 (5): (2018) 1614–1660. doi:10.1002/med.21492.

Hanan.F. Mohssen, N.M. Ali, H.A. Ali, Synthesis of new quinoline derivatives from methylene Meldrum's acid and screening the biological properties., Research Journal of Pharmaceutical, Biological and Chemical Sciences. 8(1) : (2016) 476. doi.org/10.1016/B978-0-12-819848-3.00013-X

Nagham Mahmood Aljamali, Intisar O. Alfatlawi. Synthesis of Sulfur Heterocyclic Compounds and Study of Expected Biological Activity. Research Journal of Pharmacy and Technology. 8(9): (2015) 1225-1242. doi: 10.5958/0974-360X.2015.00224.3

O. J. Edward, S.R. Kehrmeyer, G.K. Sims. "Isolation, characterization, and substrate utilization of a quinoline-degrading bacterium". International Biodeterioration & Biodegradation. 38 (2): (1996) 107-116. doi:10.1016/S0964-8305(96)00032-7.

G.W. GRIBBLE, H.W. Peter. "Reactions of Sodium Borohydride in Acidic Media; III. Reduction and Alkylation of Quinoline and Isoquinoline with Carboxylic Acids". Synthesis. 4 (10)):1975) 650–652. doi:10.1055/s-1975-23871

N. Toshimitsu, K. Mitsuharu; N. Toshiharu. "Isoquinoline Derivatives". Pharmacology of Endogenous Neurotoxins. 3(8): (1975) 3–23. doi:10.1007/978-1-4612-2000-8_1

T. Eicher, T. Hauptmann. The Chemistry of Heterocycles, 2nd ed.; Wiley-VCH: Weinheim, Germany, (2003) 316–336. doi:10.1002/352760183X


Refbacks

  • There are currently no refbacks.