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A Review on Catharanthus roseus

surya prakash dv, Prakhar Chaudhary, Anand Kumar Nelapati

Abstract


In world health care, medicinal plants have played crucial role. Catharanthus roseus commonly known as Cape periwinkle and belongs to Apocynaceae family. It is evergreen herbaceous species and native to but cultivated as a medicinal and ornamental plant species. It has a history of use in Ayurvediuc, Chinese and Western medicine research. The leaves are oval to broad, oblong, green, glossy and divided into opposite pairs and flowers have five petal-like lobes with coloured white to dark pink. It is commonly grown  as an ornamental plant but was used in traditional medicine for a long time.It containsvarious phytochemical constituets like vinblastine, vincristine, methylvingramine, catharanthine, vindoline, serpentine, rosinidin and lochnericine. It has anti-cancer effects, and is commonly used for diabetes care. This is a common ornamental plant in East Africa. This plant leaves have been used internally as antiseptic agents for wound healing. This plant rich in their pharmacological activities includes antioxidant, antifungal, antibacterial, antiviral and anticancer activates.


Keywords


Catharanthus roseus, herb, vinblastine, vindoline, antioxidant

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References


Chattopadhyay RR, Sarkar SK, Ganguli S.Hypoglycemic and antihyperglycemic effect of leaves of Vinca rosea Linn. Indian Journal of Physiology and Pharmacology. 1991; 35: 145–51.

Prajakta J Patil, Jai S. Ghosh. Antimicrobial Activity of Catharanthus roseus – A Detailed Study. British Journal of Pharmacology and Toxicology. 2010; 1(1): 40–44p.

Nayak BS, Anderson M, Pereira LMP. Evaluation of wound-healing potential of Catharanthus roseus leaf extract in rats. Journal of Fitoterapia. 2007; 78:540–544p.

Swati A, Simi J, Nikkita C, Saloni B, Ayesha T, Vedamurthy AB, Krishna V, Joy Hoskeri H. Evaluation of In-vitro Anthelminthic Activity of Catharanthus roseus Extract. International Journal of Pharmaceutical Sciences and Drug Research. 2011; 3(3): 211–213p.

Yogesh Patel. Evaluation of hypolipidemic activity of leaf juice of Catharanthus roseus (Linn.). Acta Poloniae Pharmaceutica - Drug Research. 2011; 68(6):927–935p.

S. Yokoshima, T. Ueda, S. Kobayashi. Stereocontrolled total synthesis of (+)-vinblastine. Journal of the American Chemical Society. 2002; 124(10):2137–2139p.

Kharwar R N, Verma VC, Strobel G, Ezra D. The endophytic fungal complex of Catharanthus roseus (L.) G. Don. Journal of Current Science. 2008; 95(2):228–233p.

Agarwal S, Jacob S, Chettri N. Evaluation of invitro anthelminthic activity of Catharanthus roseus extract. International Journal of Pharmaceutical Sciences and Drug Research. 2011; 3(3):211–213p.

Patil PJ, Ghosh JS. Antimicrobial activity of Catharanthusroseus—a detailed study. British Journal of Pharmacologyand Toxicology. 2010; 1:40–44p.

Deshmukhe PV, Hooli AA, Holihosur SN. Bioinsecticidal potential of Vinca rosea against the tobacco caterpillar, Spodopteralitura (Fabricius). Recent Research Science and Technology. 2010; 2(1):01–05p.

Rawat Sand Gupta. A Development and study of wound healing activity of an Ayurvedic formulation. Asian Journal of Research in Pharmaceutical Sciences. 2011; 1(1):26–28p.

Magnotta M, Murata J, Chen J, De Luca V. Identification of a low vindoline accumulating cultivar of Catharanthus roseus by alkaloid and enzymatic profiling. Journal of Phytochemistry. 2006; 67:1758–1764p.

Siddiqui MJ, Ismail AFA, Aisha AMS, Abdul M. Cytotoxic activity of Catharanthus roseus (Apocynaceae) crude extracts and pure compound against human carcinoma cell line. International Journal of Phytopharmacology. 2010; 6:43–47p.

Alba Bhutkar MA, Bhise SB. Comparative Studies on Antioxidant Properties of Catharanthus rosea and Catharanthus. International Journal of Pharmaceutical Techniques. 2011; 3(3):

–1556p.

Prajakta J. Patil, Jai S. Ghosh, Antimicrobial Activity of Catharanthus roseus – A Detailed Study. British Journal of Pharmacology and Toxicology.2010; 1(1): 40–44p.

Noble RL. The discovery of the vinca alkaloids-chemotherapeutic agents against cancer. Journal of Biochemistry and Cell Biology.1990; 68: 1344–1351p.

Ara N, Rashid M, Amran MS: Comparison of Hypotensive and Hypolipidemic effects of Catharanthus roseus leaves extract with atenolol on adrenaline induced hypertensive rats. Pak J Pharm Sci. 2009; 22: 267–271p.

Chattopadhyay RR, Sarkar SK, Ganguli S. Hypoglycemic and antihyperglycemic effect of leaves of Vincarosea Linn. Indian Journal of Physiology and Pharmacology. 1991; 35: 145–51p.

Renjini KR, Gopakumar G, Latha MS. The medicinal properties of phytochemical in Catharanthus roseus - A review. European journal of pharmaceutical and medical research. 2017; 4(11): 545–551p.

Suddhasuchi D, Amit B S. Madagascar periwinkle (Catharanthus roseus L.) Diverse medicinal and therapeutic benefits to humankind. Journal of Pharmacognosy and Phytochemistry. 2017; 6(5): 1695–1701p.


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