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Lipophilic Behaviour of Materials-A Study

Nupur Goswami, Bangshidhar Goswami, Saroj Dutta, Tridib Kumar Pathak, Indira Sinha, Bhakti Bharati Mishra, Tarun Kumar Goswami, Deep Sen

Abstract


Hydrophobicity has been integrant of lipophilicity such that impetus has differential in response to intermolecular interactions. Said scheme has elucidated lipophilicity as physicochemical property that has acted two separate definitions in subjective code, given by two types of structural contributions, i.e. bulk term to access cavity formation, hydrophobic and dispersive forces, whereas other has been polar term that has been directional electrostatic interactions like hydrogen bonds. Antibacterial activity of some 1-benzylbenzimidazole derivatives has been evaluated against Gram-negative bacteria Escherichia coli that has evidenced act from minimum inhibitory concentration for all the compounds. Quantitative structure–activity relationship (QSAR) has been employed to study the effect of lipophilicity parameters, given by log P on inhibitory activity. Log P values for target compounds have been experimentally determined by the usual shake-flask method and calculated by using eight different software products. Multiple linear regressions have been used to correlate log P values and antibacterial activity of studied benzimidazole derivatives. Thereby importance has succeeded aspect from hydrophobic or lipophilic nature of biologically active molecules. Lipophilicity has modified penetration of bioactive molecules through apolar cell membranes. Henceforth, property relevance in lieu, has been characteristic to partition coefficient i.e. log P, which has determined from distribution studies of compound between an immiscible polar and non-polar solvent pair. Otherwise, subjective quantity has been a descriptor of lipophilicity or one of key determinants of pharmacokinetic properties.


Keywords


Lipophilicity, Pharmacy, Drug delivery, Medicinal chemistry, Hydrophobic,

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References


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DOI: https://doi.org/10.37628/ijmb.v7i1.664

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